A fluoroquinolone antibiotic
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Labeled Version(s)
34226Sarafloxacin-d8 (hydrochloride)
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Sarafloxacin (hydrochloride)

Item No. 20299

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride
CAS Number
91296-87-6
Synonyms
  • A-56620
Molecular Formula
C20H17F2N3O3 • HCl
Formula Weight
421.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
280, 318, 330 nm
SMILES
O=C1C2=CC(F)=C(N3CCNCC3)C=C2N(C4=CC=C(F)C=C4)C=C1C(O)=O.Cl
InChi Code
InChI=1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H
InChi Key
KNWODGJQLCISLC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Sarafloxacin is a fluoroquinolone antibiotic.1,2 It is active against various clinical isolates of bacteria, including Bacteroides, Fusobacterium, Eubacterium, Actinomyces, and Peptococcus (MICs = 0.5-2 µg/ml).1 Sarafloxacin inhibits P. aeruginosa DNA gyrase.3 It decreases air sac lesion severity in a chick model of E. coli-induced colisepticemia when administered at a dose of 8 mg/kg in the drinking water 24 hours per day for five days.2 Formulations containing sarafloxacin have previously been used in the treatment of bacterial infections in poultry.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bansal, M.B., and Thadepalli, H. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro. Antimicrob. Agents Chemother. 31(4), 619-621 (1987).

    2. Charleston, B., Gate, J.J., Aitken, I.A., et al. Comparison of the efficacies of three fluoroquinolone antimicrobial agents, given as continuous or pulsed-water medication, against Escherichia coli infection in chickens. Antimicrob. Agents Chemother. 42(1), 83-87 (1998).

    3. Moir, D.T., Di, M., Opperman, T., et al. A high-throughput, homogeneous, bioluminescent assay for Pseudomonas aeruginosa gyrase inhibitors and other DNA-damaging agents. J. Biomol. Screen. 12(6), 855-864 (2007).