A teratogenic herbicide used to model CDH
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Nitrofen

Item No. 20341

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dichloro-1-(4-nitrophenoxy)-benzene
CAS Number
1836-75-5
Molecular Formula
C12H7Cl2NO3
Formula Weight
284.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
λmax
292 nm
SMILES
ClC1=C(OC2=CC=C([N+]([O-])=O)C=C2)C=CC(Cl)=C1
InChi Code
InChI=1S/C12H7Cl2NO3/c13-8-1-6-12(11(14)7-8)18-10-4-2-9(3-5-10)15(16)17/h1-7H
InChi Key
XITQUSLLOSKDTB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $32

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    1 g

    $61

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    5 g

    $208

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    Cayman Chemical
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    Product Description

    Nitrofen is an herbicide with potent teratogenic activity in rats and mice.1 It induces bilateral pulmonary hypoplasia and an immature lung architecture in fetal rats and mice, which is used to model human congenital diaphragmatic hernia.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manson, J.M. Mechanism of nitrofen teratogenesis. Environ. Health Perspect. 70, 137-147 (1986).

    2. Allan, D.W., and Greer, J.J. Pathogenesis of nitrofen-induced congenital diaphragmatic hernia in fetal rats. J. Appl. Physiol. 83(2), 338-347 (1997).

    3. Guilbert, T.W., Gebb, S.A., and Shannon, J.M. Lung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development. Am. J. Physiol Lung Cell. Mol. Physiol. 279(6), L1159-L1171 (2000).

    4. Pereira-Terra, P., Moura, R.S., Nogueira-Silva, C., et al. Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development. J. Physiol. 593(15), 3301-3311 (2015).