A sulfated polysaccharide with diverse biological activities
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Fucoidan

Item No. 20357

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate
CAS Number
9072-19-9
Synonyms
  • Fucan
  • Sulfated α-L-Fucan
Molecular Formula
(C6H9O3SO3)n
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
C[C@H]1O[C@H](OC2[C@H](C)O[C@@H](OC3[C@H](O[R])[C@H](C)O[C@@H](OC4[C@H](C)O[C@@H](C)[C@@H](O[R])[C@@H]4O[R])[C@H]3O[R])[C@@H](O[R])[C@@H]2O[R])[C@H](O[R])[C@@H](OC)[C@H]1O[R].CC.CC
Origin
Plant/Laminaria japonica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $95

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    500 mg

    $178

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    1 g

    $333

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    Cayman Chemical
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    Product Description

    Fucoidan is a sulfated polysaccharide that has been found in various brown algae species, including L. digitata, A. nodosum, M. pyrifera, and F. vesiculosus, and has diverse biological activities.1 Fucoidan consists of repeated (1→3)-L-fucopyranoses or alternating and repeated (1→3)- and (1→4)-L-fucopyranoses, as well as R groups composed of sulfate, uronic acid, or fucose groups. It also contains other sugars such as galactose. It has antioxidant activity in ferric reducing and DPPH (Item No. 14805) scavenging assays (IC50s = 76.8 and 93.69 µg/ml, respectively).2 Fucoidan inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in Vero cells (IC50s = 2.5 and 2.6 µg/ml, respectively).3 It also inhibits thrombin-induced aggregation of isolated human platelets when used at a concentration of 100 µg/ml.4 Fucoidan (4 mg/kg) decreases neutrophil infiltration in a rat model of peptone-induced acute peritonitis. It reduces tumor growth, inhibits angiogenesis, and decreases the number of lung metastases in a 4T1 murine model of breast cancer when administered at doses of 5 and 10 mg/kg.5 Formulations containing fucoidan have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luthuli, S., Wu, S., Cheng, Y., et al. Therapeutic effects of fucoidan: A review on recent studies. Mar. Drugs 17(9), 487 (2019).

    2. Palanisamy, S., Vinosha, M., Marudhupandi, T., et al. In vitro antioxidant and antibacterial activity of sulfated polysaccharides isolated from Spatoglossum asperum. Carbohydr. Polym. 170, 296-304 (2017).

    3. Lee, J.-B., Hayashi, K., Hashimoto, M., et al. Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu). Chem. Pharm. Bull. (Tokyo) 52(9), 1091-1094 (2004).

    4. Cumashi, A., Ushakova, N.A., Preobrazhenskaya, M.E., et al. A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 17(5), 541-552 (2007).

    5. Xue, M., Ge, Y., Zhang, J., et al. Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo. PLoS One 7(8), e43483 (2012).