An adenylate cyclase inhibitor
Related Products
Isomer(s)
366622′,3′-Dideoxyadenosine
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2',5'-dideoxy Adenosine

Item No. 20358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2',5'-dideoxy-adenosine
CAS Number
6698-26-6
Synonyms
  • 2ʹ,5ʹ-dd-Ado
  • NSC 95943
Molecular Formula
C10H13N5O2
Formula Weight
235.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
210, 259 nm
SMILES
C[C@@H]1[C@@H](O)C[C@H](N2C=NC3=C2N=CN=C3N)O1
InChi Code
InChI=1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
InChi Key
FFHPXOJTVQDVMO-DSYKOEDSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $135

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    10 mg

    $253

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    Product Description

    2',5'-dideoxy Adenosine is a nucleoside analog that is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase. It inhibits forskolin-induced activation of a cAMP-dependent reporter gene in HEK293 cells with an IC50 value of 33 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Emery, A.C., Eiden, M.V., and Eiden, L.E. A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536. Mol. Pharmacol. 83(1), 95-105 (2013).