A prodrug form of ddATP
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2′,3′-Dideoxyadenosine

Item No. 36662

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
4097-22-7
Synonyms
  • ddA
  • ddAdo
  • NSC 98700
Molecular Formula
C10H13N5O2
Formula Weight
235.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mLDMSO: 2 mg/mLEthanol: Slightly soluble
λmax
262 nm
SMILES
NC1=C2C(N([C@](CC3)([H])O[C@@H]3CO)C=N2)=NC=N1
InChi Code
InChI=1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7+/m0/s1
InChi Key
WVXRAFOPTSTNLL-NKWVEPMBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

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    Cayman Chemical
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    Product Description

    2’,3’-Dideoxyadenosine is prodrug form of the nucleoside reverse transcriptase inhibitor (NRTI) 2’,3’-dideoxyadenosine 5’-triphosphate (ddATP; Item No. 17460).1 It inhibits HIV replication in HIV-infected MT-4 cells when used at concentrations of 5 and 125 µM and protects ATH8 cells against the cytopathic effect of HIV (EC50 = 2.7 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schlienger, N., Lefebvre, I., Aubertin, A.-M., et al. Mononucleoside phosphorodithiolates as mononucleotide prodrugs. Eur. J. Med. Chem. 227, 113914 (2022).

    2. Herdewijn, P., Blazarini, J., Clercq, E.D., et al. 3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. J. Med. Chem. 30(8), 1270-1278 (1987).