An active metabolite of ceftiofur
Related Products
Parent Compound(s)
27301Ceftiofur (hydrochloride)
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Desfuroylceftiofur

Item No. 20360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(mercaptomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number
120882-22-6
Molecular Formula
C14H15N5O5S3
Formula Weight
429.5
Purity
≥80%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly, sonicated
λmax
236 nm
SMILES
SCC1=C(C(O)=O)N2[C@]([C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C2=O)([H])SC1
InChi Code
InChI=1S/C14H15N5O5S3/c1-24-18-7(6-4-27-14(15)16-6)10(20)17-8-11(21)19-9(13(22)23)5(2-25)3-26-12(8)19/h4,8,12,25H,2-3H2,1H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
InChi Key
OITCOWCNESRWSM-GHXIOONMSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Desfuroylceftiofur is an active metabolite of the broad-spectrum cephalosporin antibiotic ceftiofur (Item No. 27301).1 It is formed from ceftiofur by bovine kidney and liver esterases.2 Desfuroylceftiofur is active against 539 veterinary isolates of Gram-negative bacteria and Gram-positive cocci bacteria (MIC50s = 0.0078-1 and 0.015-4 µg/ml, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salmon, S.A., Watts, J.L., and Yancey Jr., R.J. In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. J. Vet. Diagn. Invest. 8(3), 332-336 (1996).

    2. Olson, S.C., Beconi-Barker, M.G., Smith, E.B., et al. In vitro metabolism of ceftiofur in bovine tissues. J. Vet. Pharmacol. Ther. 21(2), 112-120 (1998).