A broad-spectrum cephalosporin antibiotic
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Active Metabolite(s)
20360Desfuroylceftiofur
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Ceftiofur (hydrochloride)

Item No. 27301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrochloride
CAS Number
103980-44-5
Synonyms
  • U-64279A
  • U-67279A
Molecular Formula
C19H17N5O7S3 • HCl
Formula Weight
560.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 20 mg/mlEthanol: 15 mg/ml
λmax
288 nm
SMILES
OC(C1=C(CSC(C2=CC=CO2)=O)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC)=O)([H])N1C3=O)=O.Cl
InChi Code
InChI=1S/C19H17N5O7S3.ClH/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10;/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28);1H/b23-11-;/t12-,16-;/m1./s1
InChi Key
KEQFDTJEEQKVLM-JUODUXDSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ceftiofur is a broad-spectrum cephalosporin antibiotic.1 It is active against porcine isolates of A. pleuropneumoniae, P. multocida, S. typhimurium, S. cholerae-suis, E. coli, S. suis, and β-hemolytic streptococci with MIC90 values of less than or equal to 2 μg/ml. Ceftiofur exhibits curative rates of 43, 88, and 100% in a lactating bovine model of intramammary S. uberis infection when administered via intramammary infusion at a dose of 125 mg per infected quarter for 2, 5, and 8 days, respectively.2 Formulations containing ceftiofur have been used in the veterinary treatment of bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salmon, S.A., Watts, J.L., Case, C.A., et al. Comparison of MICs of ceftiofur and other antimicrobial agents against bacterial pathogens of swine from the United States, Canada, and Denmark. J. Clin. Microbiol. 33(9), 2435-2444 (1995).

    2. Oliver, S.P., Almeida, R.A., Gillespie, B.E., et al. Extended ceftiofur therapy for treatment of experimentally-induced Streptococcus uberis mastitis in lactating dairy cattle. J. Dairy Sci. 87(10), 3322-3329 (2004).