A calcium antagonist
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Flunarizine (hydrochloride)

Item No. 20385

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-piperazine, dihydrochloride
CAS Number
30484-77-6
Molecular Formula
C26H26F2N2 • 2HCl
Formula Weight
477.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mlEthanol: 1 mg/ml
λmax
254 nm
SMILES
FC(C=C1)=CC=C1C(C2=CC=C(F)C=C2)N(CC3)CCN3C/C=C/C4=CC=CC=C4.Cl.Cl
InChi Code
InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChi Key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    5 g

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    10 g

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    Product Description

    Flunarizine is a calcium antagonist that acts as a potent dilator of peripheral vessels without having calcium-blocking actions in the heart.1 It reduces calcium fluxes in vascular smooth muscle by blocking both voltage-dependent calcium channels and receptor-operated channels.2 Flunarizine also acts as a dopamine D2 receptor antagonist.3 Through its action as a dilator of peripheral vessels, flunarizine has a role in the prophylaxis of migraine headaches.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Singh, B.N. The mechanism of action of calcium antagonists relative to their clinical applications. Br. J. Clin. Pharmacol. 21(Suppl 2), 109S-121S (1986).

    2. Bian, K., and Toda, N. Vasodilator actions of flunarizine in isolated dog cerebral and extracerebral arteries. Jpn. J. Pharmacol. 49(1), 83-94 (1989).

    3. Brücke, T., Wöber, C., Podreka, I., et al. D2 receptor blockade by flunarizine and cinnarizine explains extrapyramidal side effects. A SPECT study. J. Cereb. Blood Flow Metab. 15(3), 513-518 (1995).

    4. Limmroth, V., and Michel, M.C. The prevention of migraine: A critical review with special emphasis on β-adrenoceptor blockers. Br. J. Clin. Pharmacol. 52(3), 237-243 (2001).

    5. Pringsheim, T., Davenport, W.J., and Becker, W.J. Prophylaxis of migraine headache. CMAJ 182(7), (2010).