An inhibitor of cardiac late sodium current
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Isomer(s)
20682R-(–)-Flecainide
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Flecainide (acetate)

Item No. 20388

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-benzamide, monoacetate
CAS Number
54143-56-5
Molecular Formula
C17H20F6N2O3 • C2H4O2
Formula Weight
474.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMWater: 25 mM
λmax
261 nm
SMILES
O=C(NCC1CCCCN1)C2=C(OCC(F)(F)F)C=CC(OCC(F)(F)F)=C2.OC(C)=O
InChi Code
InChI=1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)
InChi Key
RKXNZRPQSOPPRN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $153

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    50 mg

    $268

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    Product Description

    Flecainide is an inhibitor of cardiac late sodium current (INa; IC50 = 3.4 µM) and delayed-rectifier potassium current (IKr; IC50 = 1.5 µM).1,2,3 Formulations containing flecainide have been used in the treatment of arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ramos, E., and O'Leary, M.E. State-dependent trapping of flecainide in the cardiac sodium channel. J. Physiol. 560(Pt. 1), 37-49 (2004).

    2. Belardinelli, L., Liu, G., Smith-Maxwell, C., et al. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. J. Pharmacol. Exp. Ther. 344(1), 23-32 (2013).

    3. Gutman, G.A., Chandy, K.G., Grissmer, S., et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev. 57(4), 473-508 (2005).