A cell-permeant precursor of quin-2
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Quin-2 AM

Item No. 20422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-glycine(acetyloxy)methyl ester
CAS Number
83104-85-2
Synonyms
  • Quin-2 Acetoxymethyl ester
Molecular Formula
C38H43N3O18
Formula Weight
829.8
Purity
≥90%
Emission
492 nm
Excitation
339 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=C2C(C=CC(COC3=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C=CC(C)=C3)=N2)=CC(OC)=C1
InChi Code
InChI=1S/C38H43N3O18/c1-23-7-10-31(40(14-34(46)56-19-52-24(2)42)15-35(47)57-20-53-25(3)43)33(11-23)51-18-29-9-8-28-12-30(50-6)13-32(38(28)39-29)41(16-36(48)58-21-54-26(4)44)17-37(49)59-22-55-27(5)45/h7-13H,14-22H2,1-6H3
InChi Key
ANRZUBSJAOAXHS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $259

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    Product Description

    Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 (Item No. 20421). As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM.1 It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.1 High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.1,2 Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsien, R.Y., Pozzan, T., and Rink.T.J. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J. Cell. Biol. 947(2), 325-334 (1982).

    2. Minta, A., Kao, J.P., and Tsien, R.Y. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. The Journal of Biological Chemisty 264(14), 8171-8178 (1989).