An insecticidal mycotoxin
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Destruxin A

Item No. 20428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-pentenoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl]
CAS Number
6686-70-0
Synonyms
  • SB 242533
Molecular Formula
C29H47N5O7
Formula Weight
577.7
Purity
≥96%
Formulation
A powder
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMF: SolubleDMSO: Soluble
SMILES
O=C(N[C@]([C@@H](C)CC)([H])C(N(C)[C@@H](C(C)C)C(N(C)[C@H]1C)=O)=O)[C@@]2([H])N(CCC2)C([C@@H](CC=C)OC(CCNC1=O)=O)=O
InChi Code
InChI=1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)/t18-,19-,20-,21+,23-,24-/m0/s1
InChi Key
XIYSEKITPHTMJT-OCCJOITDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $590

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    5 mg

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    Cayman Chemical
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    Product Description

    Destruxin A is a cyclic hexadepsipeptide mycotoxin first isolated from O. destructor and commonly found in entomopathogenic fungi.1 It has insecticidal activity by affecting diverse pathways, including those related to immune response, calcium signaling, and development.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pedras, M., Zaharia, L.I., and Ward, D.E. The destruxins: Synthesis, biosynthesis, biotransformation, and biological activity. Phytochemistry 59(6), 579-596 (2002).

    2. Han, P., Jin, F., Dong, X., et al. Transcript and protein profiling analysis of the Destruxin A-induced response in larvae of Plutella xylostella. PLoS One 8(4), (2013).

    3. Pal, S., St.Leger, R.J., and Wu, L.P. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. The Journal of Biological Chemisty 282(12), 8969-8977 (2007).