An insecticidal mycotoxin
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Destruxin B

Item No. 20429

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl]
CAS Number
2503-26-6
Synonyms
  • SB 242536
  • NSC 236580
Molecular Formula
C30H51N5O7
Formula Weight
593.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: 10 mg/mlDMSO: 10 mg/ml
SMILES
O=C(N[C@]([C@@H](C)CC)([H])C(N(C)[C@@H](C(C)C)C(N(C)[C@H]1C)=O)=O)[C@@]2([H])N(CCC2)C([C@@H](CC(C)C)OC(CCNC1=O)=O)=O
InChi Code
InChI=1S/C30H51N5O7/c1-10-19(6)24-29(40)34(9)25(18(4)5)30(41)33(8)20(7)26(37)31-14-13-23(36)42-22(16-17(2)3)28(39)35-15-11-12-21(35)27(38)32-24/h17-22,24-25H,10-16H2,1-9H3,(H,31,37)(H,32,38)/t19-,20-,21-,22+,24-,25-/m0/s1
InChi Key
GNBHVMBELHWUIF-VTSYCQLTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Destruxin B is a cyclic hexadepsipeptide mycotoxin first isolated from O. destructor.1 It has insecticidal and phytotoxic activity and is prone to metabolization by plants.2,3 Destruxin B also induces apoptosis in human non-small cell lung cancer cells in culture.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pedras, M., Zaharia, L.I., and Ward, D.E. The destruxins: Synthesis, biosynthesis, biotransformation, and biological activity. Phytochemistry 59(6), 579-596 (2002).

    2. Berthiller, F., Crews, C., Dall'Asta, C., et al. Masked mycotoxins: A review. Mol. Nutr. Food Res. 57(1), 165-186 (2013).

    3. Pedras, M.S., Zaharia, I.L., Gai, Y., et al. In planta sequential hydroxylation and glycosylation of a fungal phytotoxin: Avoiding cell death and overcoming the fungal invader. Proc. Natl. Acad. Sci. USA 98(2), 747-752 (2001).

    4. Wu, C.-C., Chen, T.-H., Liu, B.-L., et al. Destruxin B isolated from entomopathogenic fungus Metarhizium anisopliae induces apoptosis via a Bcl-2 family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Evid. Based Complement. Alternat. Med. 548929 (2013).