An EphB3 kinase inhibitor
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LDN-211904

Item No. 20453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-chlorophenyl)-6-(4-piperidinyl)-imidazo[1,2-a]pyridine-3-carboxamide, monoethanedioate
CAS Number
1198408-78-4
Molecular Formula
C19H19ClN4O • C2H2O4
Formula Weight
444.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
211, 250, 303 nm
SMILES
O=C(NC1=C(Cl)C=CC=C1)C2=CN=C(C=C3)N2C=C3C4CCNCC4.OC(C(O)=O)=O
InChi Code
InChI=1S/C19H19ClN4O.C2H2O4/c20-15-3-1-2-4-16(15)23-19(25)17-11-22-18-6-5-14(12-24(17)18)13-7-9-21-10-8-13;3-1(4)2(5)6/h1-6,11-13,21H,7-10H2,(H,23,25);(H,3,4)(H,5,6)
InChi Key
ODBJGLKPAQMCJA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $241

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    Product Description

    LDN-211904 is an inhibitor of erythropoietin-producing hepatocellular carcinoma (Eph) receptors. In particular, it inhibits EphB3 (IC50 = 79 nM), a tyrosine kinase receptor (RTK) subtype expressed during embryonic development and following central nervous system damage and some cancer cell growth.1 At 5 µM, this compound was profiled for inhibitory activity against a panel of 288 kinases and found to inhibit most of the EphA and EphB receptor kinase subtypes except for EphA6 and EphA7, and is non-inhibitory towards the non-RTKs screened except for p38α, p38β, and Qik.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qiao, L., Choi, S., Case, A., et al. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioor. Med. Chem. Lett. 19(21), 6122-6126 (2009).