An active metabolite of nicotinamide
Related Products
Isomer(s)
29920JBSNF-000088
Parent Compound(s)
11127Nicotinamide
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Nudifloramide

Item No. 20507

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,6-dihydro-1-methyl-6-oxo-3-pyridinecarboxamide
CAS Number
701-44-0
Synonyms
  • N-methyl-2-Pyridone-5-Carboxamide
  • Met2PY
  • 2-Py
Molecular Formula
C7H8N2O2
Formula Weight
152.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
257, 301 nm
SMILES
O=C(N)C(C=C1)=CN(C)C1=O
InChi Code
InChI=1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)
InChi Key
JLQSXXWTCJPCBC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Product Description

    Nudifloramide is an active metabolite of the cofactor, biological intermediate, and NAD+ biosynthetic precursor nicotinamide (Item No. 11127).1 It is formed from nicotinamide via a 1-methylnicotinamide (Item No. 16604) intermediate by aldehyde oxidase (AOX). Nudifloramide is an inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 8 µM).2 Plasma levels of nudifloramide are increased in patients with chronic renal failure.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giner, M.P., Christen, S., Bartova, S., et al. A method to monitor the NAD+ metabolome - from mechanistic to clinical applications. Int. J. Mol. Sci. 22(19), 10598 (2021).

    2. Lenglet, A., Liabeuf, S., Bodeau, S., et al. N-methyl-2-pyridone-5-carboxamide (2PY)-Major metabolite of nicotinamide: An update on an old uremic toxin. Toxins (Basel) 8(11), E339 (2016).

    3. Rutkowski, B., Rutkowski, P., Słomińska, E., et al. Distribution of purine nucleotides in uremic fluids and tissues. J. Ren. Nutr. 20(5 Suppl), S7-10 (2010).