An inhibitor of NNMT
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JBSNF-000088

Item No. 29920

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-3-pyridinecarboxamide
CAS Number
7150-23-4
Synonyms
  • 6-Methoxynicotinamide
  • NSC 70628
Molecular Formula
C7H8N2O2
Formula Weight
152.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 5mg/mLDMSO:PBS (pH 7.2) (1:5): 0.16mg/mLEthanol: 1mg/mL
λmax
240, 273 nm
SMILES
NC(C1=CC=C(OC)N=C1)=O
InChi Code
InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)
InChi Key
KXDSMFBEVSJYRF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $69

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    500 mg

    $106

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    1 g

    $198

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively).1 It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO). It also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kannt, A., Rajagopal, S., Kadnur, S.K., et al. A small molecule inhibitor of nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci. Rep. 8(1), 3660 (2018).