A natural metabolite of dopamine
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3-methoxy Tyramine (hydrochloride)

Item No. 20511

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-aminoethyl)-2-methoxy-phenol, monohydrochloride
CAS Number
1477-68-5
Synonyms
  • 3-Methoxy-4-hydroxyphenethylamine
  • 3-Methoxy-p-hydroxyphenethylamine
  • 3-O-methyl Dopamine
Molecular Formula
C9H13NO2 • HCl
Formula Weight
203.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.16 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
229, 281 nm
SMILES
COC1=C(O)C=CC(CCN)=C1.Cl
InChi Code
InChI=1S/C9H13NO2.ClH/c1-12-9-6-7(4-5-10)2-3-8(9)11;/h2-3,6,11H,4-5,10H2,1H3;1H
InChi Key
AWRIOTVUTPLWLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    500 mg

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    Product Description

    3-methoxy Tyramine is a natural metabolite of dopamine, produced by catechol O-methyltransferase (COMT). It is a weak agonist of trace amine-associated receptor 1 (EC50 = 1.7 µM).1 3-methoxy Tyramine levels are assessed to monitor COMT activity in Parkinson’s disease.2 Elevated 3-methoxy Tyramine levels may also indicate abnormal catecholamine synthesis that occurs in certain neuroendocrine tumors.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wainscott, D.B., Little, S.P., Yin, T., et al. Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1. J. Pharmacol. Exp. Ther. 320(1), 475-485 (2007).

    2. Espinoza, S., Managó, F., Leo, D., et al. Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson’s disease and L-DOPA treatment. CNS Neurol. Disord. Drug Targets 11(3), 251-263 (2012).

    3. van Berkel, A., Lenders, J.W., and Timmers, H.J. Diagnosis of endocrine disease: Biochemical diagnosis of phaeochromocytoma and paraganglioma. Eur. J. Endocrinol. 170(3), R910-R119 (2014).