A metabolite of dopamine
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3-hydroxy-4-Methoxyphenethylamine (hydrochloride)

Item No. 36012

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2-aminoethyl)-2-methoxy-phenol, monohydrochloride
CAS Number
645-33-0
Synonyms
  • 4-O-methyl Dopamine
  • p-methoxy Dopamine
  • para-methoxy Dopamine
  • 4-methoxy-3-Hydroxyphenethylamine
Molecular Formula
C9H13NO2 • HCl
Formula Weight
203.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: Slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
OC1=CC(CCN)=CC=C1OC.Cl
InChi Code
InChI=1S/C9H13NO2.ClH/c1-12-9-3-2-7(4-5-10)6-8(9)11;/h2-3,6,11H,4-5,10H2,1H3;1H
InChi Key
KAAFITWSSODFMA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $32

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    50 mg

    $61

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    100 mg

    $112

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    250 mg

    $186

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    Product Description

    3-hydroxy-4-Methoxyphenethylamine is a metabolite of the catecholamine dopamine (Item Nos. 36532 | 21992).1 It is formed from dopamine by catechol-O-methyltransferase (COMT). 3-hydroxy-4-Methoxyphenethylamine (200 µM) decreases the viability of SH-SY5Y cells.2 It induces tachycardia and increases blood pressure in normotensive or DOCA-salt hypertensive rats when administered at a dose of 1 mg/kg.3 3-hydroxy-4-Methoxyphenethylamine (100 mg/kg) induces tremors and rigidity in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shoup, R.E., Davis, G.C., and Kissinger, P.T. Determination of catechol-O-methyltransferase activity in various tissues by liquid chromatography. Anal. Chem. 52(3), 483-487 (1980).

    2. Haque, M.E., Asanuma, M., Higashi, Y., et al. Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells. Biochim. Biophys. Acta 1619(1), 39-52 (2003).

    3. Gregson, R.P., Lohr, R.R., Marwood, J.F., et al. 3-Hydroxy-4-methoxyphenethylamine, the cardioactive constituent of a soft coral. Experientia 37(5), 493-494 (1981).

    4. Spoerlein, M.T., and VanderWende, C. Nature of the tremors induced by p-methoxydopamine. Life Sci. 6(19), 2029-2035 (1967).