Dydrogesterone

Dydrogesterone is a synthetic progestogen that has no estrogenic, androgenic, glucocorticoid, or anabolic effects, although it is an agonist of progesterone receptors (EC₅₀ = 12.3 nM) and an antagonist of androgen, mineralocorticoid, and glucocorticoid receptors (IC₅₀s = 28.6, 82.7, and 363 nM, respectively).^1,2 Dydrogesterone protects against sound stress-induced abortion in mice when administered at a dose of 1.25 mg per animal prior to the stressor on day five of pregnancy.³ Formulations containing dydrogesterone have been used in hormone replacement therapy, in the treatment of menstrual disorders, and to prevent miscarriage.

WARNING This product is not for human or veterinary use.

1. Coelingh Bennink, H.J., and Boerrigter, P.J. Use of dydrogesterone as a progestogen for oral contraception. Steroids 68(10-13), 927-929 (2003).

2. Rižner, T.L., Brožič, P., Doucette, C., et al. Selectivity and potency of the retroprogesterone dydrogesterone in vitro. Steroids 76(6), 607-615 (2011).

3. Joachim, R., Zenclussen, A.C., Polgar, B., et al. The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response. Steroids 68(10-13), 931-940 (2003).