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(+)-Biotin 4-Amidobenzoic Acid (sodium salt)

Item № 20534
CAS № 102418-74-6
Purity ≥98%
product image
                (CAS 102418-74-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $25.00 0.00
     10 mg $40.00 0.00
     25 mg $88.00 0.00
     50 mg $125.00 0.00

Pricing updated 2019-06-26. Prices are subject to change without notice.

Description
Synonyms
  • (+)-Biotin PABA

(+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. Biotin is an essential coenzyme for certain carboxylases and is used to modify histones and regulate gene transcription.1 Biotinidase has key roles in intestinal absorption of biotin, the transport of biotin in plasma, and in the regulation of histone biotinylation.1 (+)-Biotin 4-amidobenzoic acid is hydrolyzed by biotinidase to release 4-aminobenzoic acid (PABA), which can be quantified by either fluorescent or colorimetric methods.2 This approach is used in biotinidase activity assays in newborn screening protocols to evaluate biotinidase deficiency.3

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Technical Information
Formal Name
4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-benzoic acid, monosodium salt
CAS Number
102418-74-6
Synonyms
  • (+)-Biotin PABA
Molecular Formula
C17H20N3O4S • Na
Formula Weight
385.4
Purity
≥98%
Formulation
A crystalline solid
λmax
262 nm
SMILES
[O-]C(C1=CC=C(NC(CCCC[C@@H]2SC[C@@]3([H])[C@]2([H])NC(N3)=O)=O)C=C1)=O.[Na+]
InChI Code
InChI=1S/C17H21N3O4S.Na/c21-14(18-11-7-5-10(6-8-11)16(22)23)4-2-1-3-13-15-12(9-25-13)19-17(24)20-15;/h5-8,12-13,15H,1-4,9H2,(H,18,21)(H,22,23)(H2,19,20,24);/q;+1/p-1/t12-,13-,15-;/m0./s1
InChI Key
AMXZKFYBAOWERX-HZPCBCDKSA-M

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Zempleni, J., Hassan, Y.I., and Wigeratne, S.S.K. Biotin and biotinidase deficiency Expert. Rev. Endocrinol. Metab. 3(6), 715-724 (2008).

2. Kobza, K.A., Chaiseeda, K., Sarath, G., et al. Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase J. Nutr. Biochem. 19(12), 826-832 (2008).

3. Szabó, E., Szatmári, I., Szönyi, L., et al. Quantitative analytical method for the determination of biotinidase activity in dried blood spot samples Anal. Chem. 87(20), 10573-10578 (2015).

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