A biotinidase substrate
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(+)-Biotin 4-Amidobenzoic Acid (sodium salt)

Item No. 20534

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-benzoic acid, monosodium salt
CAS Number
102418-74-6
Synonyms
  • (+)-Biotin PABA
  • N-Biotinyl-4-aminobenzoic Acid
Molecular Formula
C17H20N3O4S • Na
Formula Weight
385.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mLPBS (pH 7.2): 1 mg/mL
λmax
262 nm
SMILES
[O-]C(C1=CC=C(NC(CCCC[C@@H]2SC[C@@]3([H])[C@]2([H])NC(N3)=O)=O)C=C1)=O.[Na+]
InChi Code
InChI=1S/C17H21N3O4S.Na/c21-14(18-11-7-5-10(6-8-11)16(22)23)4-2-1-3-13-15-12(9-25-13)19-17(24)20-15;/h5-8,12-13,15H,1-4,9H2,(H,18,21)(H,22,23)(H2,19,20,24);/q;+1/p-1/t12-,13-,15-;/m0./s1
InChi Key
AMXZKFYBAOWERX-HZPCBCDKSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $55

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    25 mg

    $120

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    50 mg

    $169

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    Product Description

    (+)-Biotin 4-amidobenzoic acid is a biotinidase substrate.1 Upon enzymatic hydrolysis, 4-aminobenzoic acid (PABA; Item No. 18659) is released which can be quantified by colorimetric detection at 540 nm in the presence of N-1-naphthylethylenediamine as a measure of biotinidase activity. (+)-Biotin 4-amidobenzoic acid has been used in the evaluation of biotinidase deficiency, an inborn error of metabolism characterized by ketolactic acidosis, hyperammonemia, and neurological dysfunction.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kobza, K.A., Chaiseeda, K., Sarath, G., et al. Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase. J. Nutr. Biochem. 19(12), 826-832 (2008).

    2. Szabó, E., Szatmári, I., Szönyi, L., et al. Quantitative analytical method for the determination of biotinidase activity in dried blood spot samples. Anal. Chem. 87(20), 10573-10578 (2015).