An antinociceptive alkaloid
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Metabolite(s)
29886(−)-Isocorypalmine
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L-Tetrahydropalmatine

Item No. 20535

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8,13,13aS-tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine
CAS Number
483-14-7
Synonyms
  • (–)-Corydalis B
  • Rotundine
  • (–)-Tetrahydropalmatine
  • (S)-Tetrahydropalmatine
  • L-THP
Molecular Formula
C21H25NO4
Formula Weight
355.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 1 mg/ml
λmax
282 nm
SMILES
COC1=CC2=C(C=C1OC)CCN3CC4=C(OC)C(OC)=CC=C4C[C@]32[H]
InChi Code
InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1
InChi Key
AEQDJSLRWYMAQI-KRWDZBQOSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

    $36

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    50 mg

    $53

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    100 mg

    $70

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    250 mg

    $86

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    Product Description

    L-Tetrahydropalmatine is an alkaloid that can be found in Corydalis yanhusuo root, which is used as an herbal remedy for pain. L-Tetrahydropalmatine has been found to have diverse effects in animals, including antagonizing the supraspinal dopamine 2 receptor and reducing stress-induced anxiety in rats.1,2 L-Tetrahydropalmatine also protects against ischemia-reperfusion injury in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, J.-Y., and Jin, G.-Z. Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine. Zhongguo Yao Li Xue Bao 20(8), 715-719 (1999).

    2. Lee, B., Sur, B., Yeom, M., et al. L-tetrahydropalmatine ameliorates development of anxiety and depression-related symptoms induced by single prolonged stress in rats. Biomol. Ther. (Seoul) (2014).

    3. Han, Y., Zhang, W., Tang, Y., et al. l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats. PLoS One 7(6), (2012).