A GSK3β inhibitor used to differentiate stem cells
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CP21R7

Item No. 20573

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS Number
125314-13-8
Molecular Formula
C19H15N3O2
Formula Weight
317.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
222, 431 nm
SMILES
NC1=CC=CC(C(C(N2)=O)=C(C3=CN(C)C4=C3C=CC=C4)C2=O)=C1
InChi Code
InChI=1S/C19H15N3O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,20H2,1H3,(H,21,23,24)
InChi Key
RGTAEYDIDMGJLX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

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    10 mg

    $329

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    25 mg

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    Product Description

    CP21R7 is a potent and selective inhibitor of GSK3β.1 It is used as an activator of stem cells prior to the induction of differentiation of stem cells to endothelial and smooth muscle cells.2,3,4 GSK3β inhibitors, including CP21R7, can be used with BMP4 to commit human pluripotent stem cells to a mesodermal fate.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gong, L., Hirschfeld, D., Tan, Y.-C., et al. Discovery of potent and bioavailable GSK-3β inhibitors. Bioorg. Med. Chem. Lett. 20(5), 1693-1696 (2010).

    2. Christensen, K., Graf, M., Iacone, R., et al. Method for differentiation of pluripotent stem cells into vascular bed cells. (2015).

    3. Patsch, C., Challet-Meylan, L., Thoma, E.C., et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat. Cell Biol. 17(8), 994-1003 (2015).

    4. Sahara, M., Hansson, E.M., Wernet, O., et al. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 24(7), 820-841 (2014).