A spin trap
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POBN

Item No. 20623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-N-[(1-oxido-4-pyridinyl)methylene]-2-propanamine-N-oxide
CAS Number
66893-81-0
Synonyms
  • 4-POBN
Molecular Formula
C10H14N2O2
Formula Weight
194.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
232, 342 nm
SMILES
[O-][N+]1=CC=C(/C=[N+]([O-])/C(C)(C)C)C=C1
InChi Code
InChI=1S/C10H14N2O2/c1-10(2,3)12(14)8-9-4-6-11(13)7-5-9/h4-8H,1-3H3/b12-8-
InChi Key
RNRMWTCECDHNQU-WQLSENKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $44

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    250 mg

    $93

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    500 mg

    $153

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    1 g

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    Product Description

    POBN is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts in in vitro studies.1,2,3,4 It is a water soluble analog of N-tert-butyl-α-phenylnitrone (Item No. 15412).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iimuro, Y., Bradford, B.U., Gao, W., et al. Detection of α-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. Mol. Pharmacol. 50, 656-661 (1996).

    2. Samokyszyn, V.M., Freeman, J.P., Maddipati, K.R., et al. Peroxidase-catalyzed oxidation of pentachlorophenol. Chem. Res. Toxicol. 8, 349-355 (1995).

    3. Iwahashi, H., Albro, P.W., McGown, S.R., et al. Isolation and identification of a-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. Arch. Biochem. Biophys. 285, 172-180 (1991).