A sulfated glycosaminoglycan mimetic
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Tramiprosate

Item No. 20701

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-1-propanesulfonic acid
CAS Number
3687-18-1
Synonyms
  • Homotaurine
  • NC 531
  • NC 758
  • NSC 77071
  • 3-Sulfopropylamine
Molecular Formula
C3H9NO3S
Formula Weight
139.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
SMILES
OS(CCCN)(=O)=O
InChi Code
InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
InChi Key
SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $120

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    10 g

    $153

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    25 g

    $336

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    Product Description

    Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation.1 Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates.2 It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gervais, F., Chalifour, R., Garceau, D., et al. Glycosaminoglycan mimetics: A therapeutic approach to cerebral amyloid angiopathy. Amyloid 8(Suppl. 1), 28-35 (2001).

    2. Santa-Maria, I., Hernandez, F., Del Rio, J., et al. Tramiprostate, a drug of potential interest for the treatment of Alzheimer’s disease, promotes an abnormal aggregation of tau. Mol. Neurodegener. 2, 17-29 (2007).

    3. Giotti, A., Luzzi, S.S., and Zilletti, L. Homotaurine: A GABAB antagonist in guinea-pig ileum. Br. J. Pharmac. 79, 855-862 (1983).