A noradrenergic neurotoxin
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DSP-4

Item No. 20707

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-bromo-N-(2-chloroethyl)-N-ethyl-benzenemethanamine, monohydrochloride
CAS Number
40616-75-9
Molecular Formula
C11H15BrClN • HCl
Formula Weight
313.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
SMILES
BrC1=C(CN(CC)CCCl)C=CC=C1.Cl
InChi Code
InChI=1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H
InChi Key
NDDRNRRNYOULND-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    DSP-4 is an alkylating agent and a noradrenergic neurotoxin that inhibits the uptake of norepinephrine in rat cortical homogenates.1 It reduces dopamine-β-hydroxylase activity in rat brain and selectively depletes norepinephrine in rat cortex and locus coeruleus over the ventral forebrain, hypothalamus, and periphery.2,1 DSP-4 (50 mg/kg) impairs tactile learning in the novel object recognition task in rats.3 It also decreases exploration in a novel open area and neophilia in a complex exploration test in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jaim-Etcheverry, G., and Zieher, L.M. DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188(2), 513-523 (1980).

    2. Grzanna, R., Berger, U., Fritschy, J.M., et al. Acute action of DSP-4 on central norepinephrine axons: Biochemical and immunohistochemical evidence for differential effects. J. Histochem. Cytochem. 37(9), 1435-1442 (1989).

    3. Rajabi, S., Shamsizadeh, A., Amini, H., et al. Effect of DSP-4 induced central noradrenergic depletion on tactile learning in rat. Neurol. Res. 34(1), 80-84 (2012).

    4. Harro, J., Oreland, L., Vasar, E., et al. Impaired exploratory behaviour after DSP-4 treatment in rats: Implications for the increased anxiety after noradrenergic denervation. Eur. Neuropsychopharmacol. 5(4), 447-455 (1995).