A typical antipsychotic
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Active Metabolite(s)
35801Perphenazine Sulfoxide
Labeled Version(s)
33298Perphenazine-d4
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Perphenazine

Item No. 20735

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
CAS Number
58-39-9
Synonyms
  • NSC 150866
  • SCH 3940
Molecular Formula
C21H26ClN3OS
Formula Weight
404.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
257, 312 nm
SMILES
ClC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChi Code
InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChi Key
RGCVKNLCSQQDEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $128

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    10 g

    $236

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    25 g

    $544

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    Product Description

    Perphenazine is a typical antipsychotic.1 It binds to dopamine D2, α1A-, α2A-, α2B-, and α2C-adrenergic, M3 muscarinic, and histamine H1 receptors (Kis = 1.4, 10, 1,848, 104.9, 85.2, 810.5 and 8 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 421, 5.6, 132, 17, and 23 nM, respectively). Perphenazine (1, 5, and 10 mg/kg) enhances morphine-induced analgesia in the tail-flick and hot plate tests in rats.2 It reduces cannibalism in female mice when administered at doses of 2 and 4 mg/kg.3 Formulations containing perphenazine have been used in the treatment of schizophrenia and psychosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003).

    2. Ozdemir, E., Bagcivan, I., and Gursoy, S. Role of D₁/D₂ dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats. Bosn. J. Basic Med. Sci. 13(2), 119-125 (2013).

    3. Carter, D.B., Kennett, M.J., and Franklin, C.L. Use of perphenazine to control cannibalism in DBA/1 mice. Comp. Med. 52(5), 452-455 (2002).