An active metabolite of perphenazine
Related Products
Parent Compound(s)
20735Perphenazine
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Perphenazine Sulfoxide

Item No. 35801

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(2-chloro-5-oxido-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
CAS Number
10078-25-8
Molecular Formula
C21H26ClN3O2S
Formula Weight
420.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 2 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): insol
λmax
239, 278 nm
SMILES
O=S1C2=C(N(CCCN3CCN(CC3)CCO)C4=CC(Cl)=CC=C41)C=CC=C2
InChi Code
InChI=1S/C21H26ClN3O2S/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)28(21)27)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChi Key
WXJXTMQMAOYROI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $74

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    10 mg

    $110

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    25 mg

    $219

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    Product Description

    Perphenazine sulfoxide is an active metabolite of the typical antipsychotic perphenazine (Item No. 20735).1 It is formed via oxidation of perphenazine. Perphenazine sulfoxide selectively binds to dopamine D2 and α1-adrenergic receptors (α1-ARs) over α2-ARs (Kis= 5.9, 24, and 683 nM, respectively) in rat brain.2 It increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets when used at a concentration of 5 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hals, P.A., Hall, H., and Dahl, S.G. Phenothiazine drug metabolites: Dopamine D2 receptor, α1- and α2-adrenoceptor binding. Eur. J. Pharmacol. 125(3), 373-381 (1986).

    2. Tharmapathy, P., Fukami, M.H., and Holmsen, H. The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombin. Biochem. Pharmacol. 60(9), 1267-1277 (2000).