An atypical antipsychotic drug
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Labeled Version(s)
33537Loxapine-d8
Metabolite(s)
217868-hydroxy Loxapine
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Loxapine (succinate)

Item No. 20760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine
CAS Number
27833-64-3
Synonyms
  • CL 71,563
Molecular Formula
C18H18ClN3O • C4H6O4
Formula Weight
445.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:9): 0.1 mg/mlEthanol: 5 mg/ml
λmax
209, 251, 297, 323 nm
SMILES
ClC1=CC2=C(C=C1)OC3=C(C=CC=C3)N=C2N4CCN(C)CC4.OC(CCC(O)=O)=O
InChi Code
InChI=1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)
InChi Key
YQZBAXDVDZTKEQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

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    500 mg

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    Product Description

    Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively).1,2 It reduces agitation associated with schizophrenia or bipolar disorder.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seeman, P., Corbett, R., and Van Tol, H.H. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology 16(2), 93-110 (1997).

    2. Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003).

    3. Zeller, S.L., and Citrome, L. Managing agitation associated with schizophrenia and bipolar disorder in the emergency setting. West J. Emerg. Med. 17(2), 165-172 (2016).