An internal standard for the quantification of loxapine
Related Products
Unlabeled Version(s)
20760Loxapine (succinate)
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Loxapine-d8

Item No. 33537

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine
CAS Number
1189455-63-7
Molecular Formula
C18H10ClD8N3O
Formula Weight
335.9
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
ClC1=CC2=C(C=C1)OC3=C(C=CC=C3)N=C2N4C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C4([2H])[2H]
InChi Code
InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3/i8D2,9D2,10D2,11D2
InChi Key
XJGVXQDUIWGIRW-JNJBWJDISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine (Item No. 20760) by GC- or LC-MS. Loxapine is an atypical antipsychotic.1 It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003).