A selective GABAA receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Picrotoxin

Item No. 20771

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione compd. with (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
CAS Number
124-87-8
Synonyms
  • Cocculin
  • NSC 403139
Molecular Formula
C15H18O7 • C15H16O6
Formula Weight
602.6
Purity
≥98% (mixture of Picrotin and Picrotoxinin)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 15 mg/ml
SMILES
C[C@]([C@@](C1)([C@]2([H])[C@]([H])(C(C)=C)[C@@]3([H])OC2=O)O)([C@]3([H])OC4=O)[C@@]54[C@@H]1O5.C[C@]([C@@](C6)([C@]7([H])[C@]([H])(C(C)(O)C)[C@@]8([H])OC7=O)O)([C@]8([H])OC9=O)[C@@]%109[C@@H]6O%10
InChi Code
InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7-,8-,9-,13-,14-,15+;6-,7+,8-,9-,10-,1
InChi Key
VJKUPQSHOVKBCO-AHMKVGDJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $41

    Add

    1 g

    $53

    Add

    5 g

    $222

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Picrotoxin is a natural plant-derived poison that acts as a selective GABAA receptor antagonist.1,2 It is functional in vivo and is used to study the role of GABAA receptors in the central nervous system as well in the periphery.3,4 Picrotoxin induces seizures in adult and immature animals and is used to study GABAA-dependent seizures and drugs that block this pathway.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bowery, N.G., Bettler, B., Froestl, W., et al. International union of pharmacology. XXXIII. Mammalian g-aminobutyric acidB receptors: Structure and function. Pharmacol. Rev. 54(2), 247-264 (2002).

    2. Newland, C.F., and Cull-Candy, S.G. On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. J. Physiol. 447, 191-213 (1992).

    3. Jiang, X., Fuller, T.W., Bandari, J., et al. Contribution of GABAA, glycine, and opioid receptors to sacral neuromodulation of bladder overactivity in cats. J. Pharmacol. Exp. Ther. 359(3), 436-441 (2016).

    4. Kistsen, V., Evstigneev, V., Dubovik, B., et al. The effects of repetitive transcranial magnetic stimulation on picrotoxin-induced convulsions in mice. Adv. Clin. Exp. Med. 25(2), 317-325 (2016).

    5. Velisek, L., Veliskova, J., and Moshe, S.L. Developmental seizure models. Ital. J. Neurol. Sci. 16(1-2), 127-133 (1995).