A dopamine D2 receptor antagonist
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Chlorprothixene (hydrochloride)

Item No. 20772

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride
CAS Number
6469-93-8
Synonyms
  • cis-Chlorprothixene
  • NSC 169899
Molecular Formula
C18H18ClNS • HCl
Formula Weight
352.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
230, 270, 329 nm
SMILES
ClC1=CC2=C(C=C1)SC3=CC=CC=C3/C2=C/CCN(C)C.Cl
InChi Code
InChI=1S/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H/b14-7-;
InChi Key
YWKRLOSRDGPEJR-KIUKIJHYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Cayman Chemical
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    Product Description

    Chlorprothixene is a thioxanthine antipsychotic that functions by antagonizing dopamine D2 receptors.1 It can block a subset of GABAA receptors in rat cortex that is also blocked by clozapine (Item No. 12059).2 It has also been shown to be effective against P. falciparum growth with an EC50 value of 1.7 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Froimowitz, M., and Cody, V. Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists. J. Med. Chem. 36(15), 2219-2227 (1993).

    2. Squires, R.F., and Saederup, E. Clozapine and several other antipsychotic/antidepressant drugs preferentially block the same “core” fraction of GABAA receptors. Neurochem. Res. 23(10), 1283-1290 (1998).

    3. Weisman, J.L., Liou, A.P., Shelat, A.A., et al. Searching for new antimalarial therapeutics amongst known drugs. Chem. Biol. Drug Des. 67(6), 409-416 (2006).