A weak estrogen with neuroprotective effects
Related Products
Parent Compound(s)
ISO6015517β-Estradiol (CRM)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

17α-Estradiol

Item No. 20776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17α)-estra-1,3,5(10)-triene-3,17-diol
CAS Number
57-91-0
Synonyms
  • Alfatradiol
  • α-Estradiol
  • 17-epi Estradiol
  • NSC 20293
  • 17α-Oestradiol
Molecular Formula
C18H24O2
Formula Weight
272.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/mlEthanol: 2.5 mg/ml
SMILES
O[C@@H]1CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])CCC4=C3C=CC(O)=C4
InChi Code
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
InChi Key
VOXZDWNPVJITMN-SFFUCWETSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $44

    Add

    100 mg

    $84

    Add

    500 mg

    $152

    Add

    1 g

    $215

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    17α-Estradiol is the natural optical isomer of 17β-estradiol (Item No. 10006315), the major estrogen secreted by the premenopausal ovary. 17α-Estradiol is a less active isomer than its counterpart, displaying 100-fold lower estrogenic activity relative to 17β-estradiol.1 It can inhibit 5α-reductase, which plays a role in regulating hair growth. 17α -estradiol is reported to activate the MAPK/ERK and PI3K-Akt signaling pathways via activation of the estrogen receptor-X and has been shown to be neuroprotective after an ischemic stroke and oxidative stress and in transgenic mice with Alzheimer’s disease.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Toran-Allerand, C.D., Tinnikov, A.A., Singh, R.J., et al. 17α-estradiol: A brain-active estrogen? Endocrinology 146(9), 3843-3850 (2005).

    2. Green, P.S., Bishop, J., and Simpkins, J.W. 17α-estradiol exerts neuroprotective effects on SK-N-SH cells. J. Neurosci. 17(2), 511-515 (1997).