A neuroprotective amino acid
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L-Theanine

Item No. 20832

Technical Information
Formal Name
N-ethyl-L-glutamine
CAS Number
3081-61-6
Synonyms
  • L-Glutamic Acid γ-ethyl amide
  • γ-ethylamino-L-Glutamic Acid
  • 5-N-ethyl-Glutamine
  • NSC 21308
Molecular Formula
C7H14N2O3
Formula Weight
Purity
≥95%
A crystalline solid
PBS (pH 7.2): 10 mg/ml
SMILES
OC([C@@H](N)CCC(NCC)=O)=O
InChi Code
InChI=1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
InChi Key
DATAGRPVKZEWHA-YFKPBYRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    L-Theanine is the major amino acid found in Camellia sinensis, the source of green tea.1 It is an analog of the excitatory neurotransmitter, glutamate, and thusly, binds to glutamate receptors.2 L-Theanine can antagonize various glutamate receptor subtypes as well as inhibit glutamine and glutamate transporters, which has been shown to be neuroprotective in animal models of focal cerebral ischemia.2,3 Further, L-theanine is reported to increase brain levels of dopamine, serotonin, GABA, nerve growth factor, and brain-derived neurotrophic factor.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thippeswamy, R., Gouda, K.G., Roa, D.H., et alDetermination of theanine in commercial tea by liquid chromatography with fluorescence and diode array ultraviolet detection. J. Agric. Food Chem. 54(19), 7014-7019 (2006).

    2. Eschenauer, G., and Sweet, B.V. Pharmacology and therapeutic uses of theanine. Am. J. Health Syst. Pharm. 63(1), 26, 28-30 (2006).

    3. Nathan, P.J., Lu, K., Gray, M., et alThe neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J. Herb. Pharmacother. 6(2), 21-30 (2006).