A selective eEF-2K inhibitor
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TX-1918

Item No. 20840

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-hydroxy-3,5-dimethylphenyl)methylene]-4-cyclopentene-1,3-dione
CAS Number
503473-32-3
Molecular Formula
C14H12O3
Formula Weight
228.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: slightlyDMSO: 0.33 mg/mlEthanol: slightly
λmax
220, 248, 370 nm
SMILES
CC1=C(O)C(C)=CC(/C=C2C(C=CC\2=O)=O)=C1
InChi Code
InChI=1S/C14H12O3/c1-8-5-10(6-9(2)14(8)17)7-11-12(15)3-4-13(11)16/h3-7,17H,1-2H3
InChi Key
YHWRISYBKMXSGJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $176

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    Product Description

    TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).1 It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).1 TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 (Item No. 10010248).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hori, H., Nagasawa, H., Ishibashi, M., et al. TX-1123: An antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioor. Med. Chem. Lett. 10(10), 3257-3265 (2002).