An inhibitor of actin assembly and cytokinesis
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Dihydrocytochalasin B

Item No. 20845

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-4,5,6,7,8,9,10,12a,13,14,15,15a,16,17-tetradecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(3H)-dione
CAS Number
39156-67-7
Synonyms
  • DCB
Molecular Formula
C29H39NO5
Formula Weight
481.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:20): 0.05 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
O=C1CC[C@H](O)CCC[C@@H](C)C/C=C/[C@]([C@H](O)C([C@@H](C)[C@@]2([H])[C@H](CC3=CC=CC=C3)NC4=O)=C)([H])[C@@]24O1
InChi Code
InChI=1S/C29H39NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14,18-19,22-24,26-27,31,33H,3,7,9-10,13,15-17H2,1-2H3,(H,30,34)/b14-8+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChi Key
WIULKAASLBZREV-RXPQEOCGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly.1 It blocks cleavage furrow formation and cytokinesis in synchronous HeLa cells at a concentration of 10 μM. DCB induces tetraploidy and arrests the cell cycle indefinitely in the G1 phase in REF-52 cells.2 It also increases the drug sensitivity of multidrug resistant SKVLB1 cells to paclitaxel (Item No. 10461) and doxorubicin (Item No. 15007) in vitro.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martineau, S.N., Andreassen, P.R., and Margolis, R.L. Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: Retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery. J. Cell. Biol. 131(1), 191-205 (1995).

    2. Andreassen, P.R., Lohez, O.D., Lacroix, F.B., et al. Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol. Biol. Cell 12(5), 1315-1328 (2001).

    3. Trendowski, M., Christen, T.D., Acquafondata, C., et al. Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro. BMC Cancer 15:632, (2015).