A selective estrogen receptor modulator
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Labeled Version(s)
30728Toremifene-d6
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Toremifene (citrate)

Item No. 20854

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine, 2-hydroxy-1,2,3-monopropanetricarboxylate
CAS Number
89778-27-8
Synonyms
  • GTx-006
  • NK 622
  • NSC 613680
Molecular Formula
C26H28ClNO • C6H8O7
Formula Weight
598.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
236, 276 nm
SMILES
ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O
InChi Code
InChI=1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
InChi Key
IWEQQRMGNVVKQW-OQKDUQJOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

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    250 mg

    $145

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    500 mg

    $268

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    Product Description

    Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen (Item No. 13258).1 It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goldstein, S.R., Siddhanti, S., Ciaccia, A.V., et al. A pharmacological review of selective oestrogen receptor modulators. Hum. Reprod. Update 6(3), 212-224 (2000).