An estrogen receptor antagonist
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Tamoxifen

Item No. 13258

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine
CAS Number
10540-29-1
Synonyms
  • TMX
Molecular Formula
C26H29NO
Formula Weight
371.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 2 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
238, 278 nm
SMILES
CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3
InChi Code
InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
InChi Key
NKANXQFJJICGDU-QPLCGJKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 mg

    $72

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    1 g

    $137

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    5 g

    $609

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    10 g

    $930

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    Cayman Chemical
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    Product Description

    Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor).1 It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM.2 Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively).3 It decreases tumor proliferation, weight, and volume in an MCF-7 mouse xenograft model when administered at a dose of 100 µg/animal per day.4 Tamoxifen (0.8 mg/kg every two weeks) also reduces proteinuria and increases survival in an NZBWF1 mouse model of systemic lupus erythematosus (SLE).5 It can be used as a regulator for Cre-recombinase inducible gene expression in vivo.6 Formulations containing tamoxifen have been used in the treatment of estrogen receptor-positive breast cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Löser, R., Seibel, K., Roos, W., et al. In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen. Eur. J. Cancer Clin. Oncol. 21(8), 985-990 (1985).

    2. Lippman, M., Bolan, G., and Huff, K. The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 36(12), 4595-4601 (1976).

    3. Dolan, K., Montgomery, S., Buchheit, B., et al. Antifungal activity of tamoxifen: In vitro and in vivo activities and mechanistic characterization. Antimicrob. Agents Chemother. 53(8), 3337-3346 (2009).

    4. Long, B.J., Jelovac, D., Handratta, V., et al. Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model. J. Natl. Cancer Inst. 96(6), 456-465 (2004).

    5. Wu, W.-M., Lin, B.-F., Su, Y.-C., et al. Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 mice. Scand. J. Immunol. 52(4), 393-400 (2000).

    6. Chen, M., Lichtler, A.C., Sheu, T.-J., et al. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 45(1), 44-50 (2007).

    Product Citations

    Isotani, R., Igarashi, M., Miura, M., et al. Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway. Elife 13, RP95267 (2025).

    Wang, X., Shelton, S.D., Bordieanu, B., et al. Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers. Nat. Aging 2(2), s43587-43021-00164-x. (2024).

    Tsukui, D., Kimura, Y., and Kono, H. GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis. iScience 26(8), 107293 (2023).

    Morrow, N.M., Burke, A.C., Samsoondar, J.P., et al. The citrus flavonoid nobiletin confers protection frommetabolic dysregulation in high-fat-fed mice independent of AMPK. J. Lipid Res. 61(3), 387-402 (2020).