A metabolite of benzene
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S-Phenylmercapturic Acid

Item No. 20869

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-S-phenyl-L-cysteine
CAS Number
4775-80-8
Synonyms
  • NSC 17197
  • S-PMA
Molecular Formula
C11H13NO3S
Formula Weight
239.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/mlEthanol: 5 mg/ml
λmax
254 nm
SMILES
OC([C@@H](NC(C)=O)CSC1=CC=CC=C1)=O
InChi Code
InChI=1S/C11H13NO3S/c1-8(13)12-10(11(14)15)7-16-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
InChi Key
CICOZWHZVMOPJS-JTQLQIEISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Product Description

    S-Phenylmercapturic acid (S-PMA) is a metabolite of benzene used as a biomarker for benzene exposure in humans.1 In industrial workers, urinary concentrations of up to 543 µg/g creatinine have been detected. In a study of benzene exposure through tobacco smoke inhalation in humans, smokers had a urinary concentration of 9.1 µg S-PMA/g creatinine compared with 4.8 µg S-PMA/g creatinine in non-smokers.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Sittert, N.J., Boogaard, P.J., and Beulink, G.D. Application of the urinary S-phenylmercapturic acid test as a biomarker for low levels of exposure to benzene in industry. Br. J. Ind. Med. 50(5), 460-469 (1993).

    2. Melikian, A.A., O'Connor, R., Prahalad, A.K., et al. Determination of the urinary benzene metabolites S-phenylmercapturic acid and trans,trans-muconic acid by liquid chromatography-tandem mass spectrometry. Carcinogenesis 20(4), 719-726 (1999).