An inhibitor of PCSK9 translation
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PF-06446846 (hydrochloride)

Item No. 20914

Product Insert (PDF)
Technical Information
Formal Name
N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)-benzamide, hydrochloride
CAS Number
1632250-50-0
Molecular Formula
C22H20ClN7O • XHCl
Formula Weight
433.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=CC=CN=C1N([C@H]2CNCCC2)C(C3=CC=C(N4N=NC5=C4N=CC=C5)C=C3)=O.Cl
InChi Code
InChI=1S/C22H20ClN7O.ClH/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21;/h2-3,5-10,12-13,17,24H,1,4,11,14H2;1H/t17-;/m1./s1
InChi Key
AQSJYIVIWBIHOU-UNTBIKODSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $138

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    10 mg

    $262

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    25 mg

    $379

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    50 mg

    $550

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    PF-06446846 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) translation.1 It inhibits translation of mRNA encoding PCSK9 by isolated human ribosomes when used at a concentration of 100 µM. PF-06446846 also inhibits PCSK9 secretion by Huh7 cells (IC50 = 0.3 µM). In vivo, PF-06446846 (50 mg/kg) decreases plasma levels of Pcsk9, total cholesterol, and LDL cholesterol in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lintner, N.G., McClure, K.F., Petersen, D., et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 15(3), e2001882 (2017).