A methylxanthine derivative and an adenosine receptor antagonist
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Proxyphylline

Item No. 20937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione
CAS Number
603-00-9
Synonyms
  • Monophylline
  • NSC 163343
Molecular Formula
C10H14N4O3
Formula Weight
238.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
273, 324 nm
SMILES
CN(C(N1C)=O)C2=C(N(CC(O)C)C=N2)C1=O
InChi Code
InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
InChi Key
KYHQZNGJUGFTGR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $54

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    1 g

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    5 g

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    10 g

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    Product Description

    Proxyphylline is a methylxanthine derivative and an adenosine receptor antagonist (Ki = 130 µM).1 It increases coronary flow in isolated guinea pig perfused heart.2 Proxyphylline reduces systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg twice per day for nine days.3 It reduces the thromboplastin activity of murine trophoblast cells when administered at a dose of 30 µg/animal intraperitoneally.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruns, R.F. Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts. Biochem. Pharmacol. 30(4), 325-333 (1981).

    2. Takeda, K., Katano, Y., Nakagawa, Y., et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture (theoesberiven) on the heart and the coronary circulation. Jpn. J. Pharmacol. 27(5), 709-720 (1977).

    3. Korzycka, L., and Górska, D. Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline. J. Pharm. Pharmacol. 60(5), 637-645 (2008).

    4. Dalaker, K., and Prydz, H. Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo. Biochem. Pharmacol. 35(20), 3433-3439 (1986).