A synthetic progestin
Related Products
Isomer(s)
33230Norethynodrel
Labeled Version(s)
33277Norethindrone-d6
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Norethindrone

Item No. 20941

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17α-hydroxy-19-norpregn-4-en-20-yn-3-one
CAS Number
68-22-4
Synonyms
  • Norethisterone
  • NSC 9564
  • SC 4640
Molecular Formula
C20H26O2
Formula Weight
298.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 1 mg/mlEthanol: 1 mg/mlMethanol: 1 mg/ml
λmax
239 nm
SMILES
O=C1CC[C@@]2([H])C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(C#C)O)=C1
InChi Code
InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1
InChi Key
VIKNJXKGJWUCNN-XGXHKTLJSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Ambient in continental US; may vary elsewhere
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    250 mg

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    Product Description

    Norethindrone is a synthetic progestin.1 In vivo, norethindrone (0.5 mg/animal per day) inhibits the estrous cycle in female mice. It induces tumor progression and metastasis in a BT474 breast cancer mouse xenograft model.2 Formulations containing norethindrone have been used as oral contraceptives.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruce, H.M. Preliminary note on the effect of 19-norethisterone on mating behavior and fertility in the mouse. Proc. Soc. Study Fertility 10, 158-165 (1958).

    2. Liang, Y., Benakanakere, I., Besch-Williford, C., et al. Synthetic progestins induce growth and metastasis of BT-474 human breast cancer xenografts in nude mice. Menopause 17(5), 1040-1047 (2010).