A CXCR2 antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Danirixin

Item No. 20980

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-urea
CAS Number
954126-98-8
Synonyms
  • GSK1325756
Molecular Formula
C19H21ClFN3O4S
Formula Weight
441.9
Purity
≥98%
Formulation
A crystalline solid
λmax
266, 323 nm
SMILES
FC1=CC=CC(NC(NC2=CC=C(Cl)C(S([C@H]3CCCNC3)(=O)=O)=C2O)=O)=C1C
InChi Code
InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1
InChi Key
NGYNBSHYFOFVLS-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $195

    Add

    10 mg

    $302

    Add

    25 mg

    $696

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Danirixin is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2; IC50 = 12.5 µM).1 It is selective for CXCR2 over CXCR1 (IC50 = 977 nM). Danirixin inhibits IL-8-induced calcium mobilization in CHO-K1 cells expressing human CXCR2 (pA2 = 7.52). It inhibits neutrophil surface expression of CD11b in isolated rat whole blood (IC50 = 890 nM). Danirixin reduces bronchoalveolar lavage fluid (BALF) neutrophil infiltration in rat models of LPS- or ozone-induced pulmonary neutrophilia (ED50s = 1.4 and 16 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Busch-Petersen, J., Carpenter, D.C., Burman, M., et al. Danirixin: A reversible and selective antagonist of the CXC chemokine receptor 2. J. Pharmacol. Exp. Ther. 362(2), 338-346 (2017).