A glucokinase activator
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AM2394

Item No. 20992

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-urea
CAS Number
1442684-77-6
Molecular Formula
C22H25N5O4
Formula Weight
423.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
λmax
269 nm
SMILES
CC1=CC(OC2=CC(NC(NC)=O)=NC=C2C3=CC=C(OCC(C)(O)C)N=C3)=CN=C1
InChi Code
InChI=1S/C22H25N5O4/c1-14-7-16(11-24-9-14)31-18-8-19(27-21(28)23-4)25-12-17(18)15-5-6-20(26-10-15)30-13-22(2,3)29/h5-12,29H,13H2,1-4H3,(H2,23,25,27,28)
InChi Key
QUISANLDBDCMPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    AM2394 is an activator of glucokinase with an EC50 value of 60 nM in an enzyme assay in the presence of glucose.1 Oral administration of AM2394 (3-30 mg/kg) decreases plasma glucose levels in an oral glucose tolerance test in an ob/ob mouse model of diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dransfield, P.J., Pattaropong, V., Lai, S., et al. Novel series of potent glucokinase activators leading to the discovery of AM-2394. ACS Med. Chem. Lett. 7(7), 714-718 (2016).