A calcium channel inhibitor
Related Products
Labeled Version(s)
31785Nisoldipine-d6
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Nisoldipine

Item No. 20998

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-(2-methylpropyl) ester
CAS Number
63675-72-9
Synonyms
  • (±)-BAY-K-5552
  • (±)-Nisoldipine
Molecular Formula
C20H24N2O6
Formula Weight
388.4
Purity
≥97%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 3 mg/ml
λmax
235, 330 nm
SMILES
CC(N([H])C(C)=C1C(OCC(C)C)=O)=C(C(OC)=O)C1C2=C([N+]([O-])=O)C=CC=C2
InChi Code
InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChi Key
VKQFCGNPDRICFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $29

    Add

    250 mg

    $70

    Add

    500 mg

    $110

    Add

    1 g

    $156

    Add
    Product Description

    Nisoldipine is a calcium channel inhibitor.1 It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.2,1 Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).1 In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.3 Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.4 Formulations containing nisoldipine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Knorr, A. The pharmacology of nisoldipine. Cardiovasc. Drugs Ther. 1(4), 393-402 (1987).

    2. Janis, R.A., Shrikhande, A.V., Greguski, R., et al. Review of nisoldipine binding studies. Nisoldipine 1987 27-35 (1987).

    3. Fagbemi, O., and Parratt, J.R. Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia. Br. J. Pharmacol. 74(1), 12-14 (1981).

    4. Stasch, J.-P., Kazda, S., Hirth, C., et al. Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats. Hypertension 10(3), 303-307 (1987).