An internal standard for the quantification of nisoldipine
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Unlabeled Version(s)
20998Nisoldipine
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Nisoldipine-d6

Item No. 31785

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl 5-(2-(methyl-d3)propyl-3,3,3-d3) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number
1285910-03-3
Molecular Formula
C20H18D6N2O6
Formula Weight
394.5
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
CC(NC(C)=C1C(OCC(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C(C(OC)=O)C1C2=C([N+]([O-])=O)C=CC=C2
InChi Code
InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3/i1D3,2D3
InChi Key
VKQFCGNPDRICFG-WFGJKAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $174

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    1 mg

    $329

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    Product Description

    Nisoldipine-d6 is intended for use as an internal standard for the quantification of nisoldipine (Item No. 20998) by GC- or LC-MS. Nisoldipine is a calcium channel inhibitor.1 It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.1,2 Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).1 In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.3 Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.4 Formulations containing nisoldipine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Knorr, A. The pharmacology of nisoldipine. Cardiovasc. Drugs Ther. 1(4), 393-402 (1987).

    2. Janis, R.A., Shrikhande, A.V., Greguski, R., et al. Review of nisoldipine binding studies. Nisoldipine 1987 27-35 (1987).

    3. Fagbemi, O., and Parratt, J.R. Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia. Br. J. Pharmacol. 74(1), 12-14 (1981).

    4. Stasch, J.-P., Kazda, S., Hirth, C., et al. Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats. Hypertension 10(3), 303-307 (1987).