Salbutamol

Salbutamol is an agonist of the β₂-adrenergic receptor (β₂-AR).¹ It induces bronchodilation in isolated guinea pig trachea rings (EC₅₀ = 19 nM). Salbutamol selectively binds to the β₂-AR over the β₁-AR and β₃-AR in CHO cells expressing the human receptors (K_ds = 0.76, 21, and 46 μM, respectively).² Salbutamol (25 and 50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.³ It also reduces the response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (ED₅₀ = 43.6 μg/animal).⁴ Formulations containing salbutamol have been used in the prevention of exercise-induced asthma and the prevention or treatment of chronic obstructive pulmonary disease (COPD).

WARNING This product is not for human or veterinary use.

1. Kern, C., Meyer, T., Droux, S., et al. Synthesis and pharmacological characterization of β₂-adrenergic agonist enantiomers: Zilpaterol. J. Med. Chem. 52(6), 1773-1777 (2009).

2. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β₂ and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).

3. Cullum, V.A., Farmer, J.B., Jack, D., et al. Salbutamol: A new, selective β-adrenoceptive receptor stimulant. Br. J. Pharmacol. 35(1), 141-151 (1969).

4. Arroyo, M.G., Couëtil, L.L., Nogradi, N., et al. Efficacy of inhaled levalbuterol compared to albuterol in horses with recurrent airway obstruction. J. Vet. Intern. Med. 30(4), 1333-1337 (2016).