A β2-AR agonist
Related Products
Isomer(s)
21003Salbutamol
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(R)-Salbutamol (hydrochloride)

Item No. 23991

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α1R-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol, monohydrochloride
CAS Number
50293-90-8
Synonyms
  • Levosalbutamol
  • (–)-Salbutamol
Molecular Formula
C13H21NO3 • HCl
Formula Weight
275.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 12 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
228, 276 nm
SMILES
OCC1=C(O)C=CC([C@@H](O)CNC(C)(C)C)=C1.Cl
InChi Code
InChI=1S/C13H21NO3.ClH/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;/h4-6,12,14-17H,7-8H2,1-3H3;1H/t12-;/m0./s1
InChi Key
OWNWYCOLFIFTLK-YDALLXLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    (R)-Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR).1 It induces relaxation of isolated guinea pig tracheal chains (EC50 = 16 nM). (R)-Salbutamol selectively binds to the β2-AR over the β1-AR (Kds = 0.236 and 1.54 µM, respectively).2 Nebulized (R)-salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (ED50 = 39.7 μg/animal).3 Formulations containing (R)-salbutamol have been used in the treatment or prevention of bronchospasm in patients with reversible obstructive airway disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hawkins, C.J., and Hawkins, G.T. Relative potency of (–)- and (±)-salbutamol on guinea pig tracheal tissue. J. Med. Chem. 16(7), 856-857 (1973).

    2. Penn, R.B., Frielle, T., McCullough, J.R., et al. Comparison of R-, S-, and RS-albuterol interaction with human β1- and β2-adrenergic receptors. Clin. Rev. Allergy Immunol. 14(1), 37-45 (1996).

    3. Arroyo, M.G., Couëtil, L.L., Nogradi, N., et al. Efficacy of inhaled levalbuterol compared to albuterol in horses with recurrent airway obstruction. J. Vet. Intern. Med. 30(4), 1333-1337 (2016).