An activator of caspases
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Ubiquitin Isopeptidase Inhibitor I

Item No. 21006

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide
CAS Number
108477-18-5
Synonyms
  • NSC 144303
Molecular Formula
C19H14N2O7S
Formula Weight
414.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
319 nm
SMILES
O=C(/C(CS(C/1)(=O)=O)=C\C2=CC=C([N+]([O-])=O)C=C2)C1=C/C3=CC=C([N+]([O-])=O)C=C3
InChi Code
InChI=1S/C19H14N2O7S/c22-19-15(9-13-1-5-17(6-2-13)20(23)24)11-29(27,28)12-16(19)10-14-3-7-18(8-4-14)21(25)26/h1-10H,11-12H2/b15-9-,16-10-
InChi Key
SSAMIOWVUGBIJK-VULZFCBJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 µM).1 It has also been shown to induce necrosis in apoptosis-resistant DKO cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aleo, E., Henderson, C.J., Fontanini, A., et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66(18), 9235-9244 (2006).

    2. Fontanini, A., Foti, C., Potu, H., et al. The isopeptidase inhibitor G5 triggers a caspase-independent necrotic death in cells resistant to apoptosis: A comparative study with the proteasome inhibitor bortezomib. The Journal of Biological Chemisty 284(13), 8369-8381 (2009).