A dual modulator of bone cell differentiation
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Bone Growth & Remodeling

ethyl 2,5-Dihydroxybenzoate

Item No. 21013

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-dihydroxy-benzoic acid, ethyl ester
CAS Number
3943-91-7
Synonyms
  • ethyl Gentisate
Molecular Formula
C9H10O4
Formula Weight
182.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
216, 238, 339 nm
SMILES
OC1=C(C(OCC)=O)C=C(O)C=C1
InChi Code
InChI=1S/C9H10O4/c1-2-13-9(12)7-5-6(10)3-4-8(7)11/h3-5,10-11H,2H2,1H3
InChi Key
GCUPAENRSCPHBM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $40

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    5 g

    $187

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    Product Description

    ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation. It promotes osteoblast differentiation, enhancing alkaline phosphatase activity, osteocalcin expression, and calcium deposition in human mesenchymal stem cells.1 ethyl 2,5-Dihydroxybenzoate also inhibits RANKL-activated osteoclastogenesis in RAW 264.7 cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kwon, B.-J., Lee, M.H., Koo, M.-A., et al. Ethyl-2, 5-dihydroxybenzoate displays dual activity by promoting osteoblast differentiation and inhibiting osteoclast differentiation. Biochem. Biophys. Res. Commun. 471(3), 335-341 (2016).