A partial agonist of CB1 and CB2 receptors
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BAY 59-3074

Item No. 21036

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4,4-trifluoro-1-butanesulfonic acid, 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl ester
CAS Number
406205-74-1
Molecular Formula
C18H13F6NO4S
Formula Weight
453.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 100 mM
λmax
294 nm
SMILES
O=S(OC1=CC(OC2=CC=CC(C(F)(F)F)=C2C#N)=CC=C1)(CCCC(F)(F)F)=O
InChi Code
InChI=1S/C18H13F6NO4S/c19-17(20,21)8-3-9-30(26,27)29-13-5-1-4-12(10-13)28-16-7-2-6-15(14(16)11-25)18(22,23)24/h1-2,4-7,10H,3,8-9H2
InChi Key
LWUSZIVDPJPVBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $143

    Add

    10 mg

    $236

    Add

    50 mg

    $929

    Add
    Cannabinoid Resource Center
    Discover Our Tools to Support Cannabinoid Research and Analysis.
    • Cannabinoid signaling research products
    • Analytical standards and certified reference materials
    • Endocannabinoid profiling services
    • Lab wall posters
    • Articles, application notes, and webinars
    LEARN MORE
    Product Description

    BAY 59-3074 is a partial agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 55.4, 48.3, and 45.5 nM for rat CB1, human CB1, and human CB2, respectively).1 BAY 59-3074 is orally active and exhibits anti-hyperalgesic and anti-allodynic properties in rat models of chronic neuropathic and inflammatory pain.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. De Vry, J., and Jentzsch, K.R. Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. Eur. J. Pharmacol. 505(1-3), 127-133 (2004).

    2. Teng, H., Thakur, G.A., and Makriyannis, A. Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands. Bioorg. Med. Chem. Lett. 21(19), 5999-6002 (2011).

    3. De Vry, J., Denzer, D., Reissmueller, E., et al. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A novel cannabinoid CB1/CB2 receptor partial agonist with antihyperalgesic and antiallodynic effects. J. Pharmacol. Exp. Ther. 310(2), 620-632 (2004).